Ontology highlight
ABSTRACT:
SUBMITTER: Ma M
PROVIDER: S-EPMC4022763 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20140424 1
<h4>Objective</h4>Accumulating evidence suggests that inflammation plays a role in the pathophysiology of major depression. The adenosine triphosphate (ATP)-sensitive P2X7 receptor (P2X7R) plays a crucial role in microglial activation caused by inflammation. The dye brilliant blue G (BBG) is a P2X7R antagonist. This study examined whether BBG shows antidepressant effects in an inflammation-induced model of depression.<h4>Methods</h4>We examined the effects of BBG (12.5, 25, or 50 mg/kg) on serum ...[more]