Class D ?-lactamases: are they all carbapenemases?
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ABSTRACT:
SUBMITTER: Antunes NT
PROVIDER: S-EPMC4023754 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Class D β-lactamases: are they all carbapenemases?
Antunes Nuno T NT Lamoureaux Toni L TL Toth Marta M Stewart Nichole K NK Frase Hilary H Vakulenko Sergei B SB
Antimicrobial agents and chemotherapy 20140127 4
Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are enzymes of the utmost clinical importance due to their ability to produce resistance to carbapenems, the antibiotics of last resort for the treatment of various life-threatening infections. The vast majority of these enzymes have been identified in Acinetobacter spp., notably in Acinetobacter baumannii. The OXA-2 and OXA-10 enzymes predominantly occur in Pseudomonas aeruginosa and are currently classified as narrow-spectrum class D β-lactam ...[more]
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