Heteronuclear Gd-(99m)Tc Complex of DTPA-Bis(histidylamide) Conjugate as a Bimodal MR/SPECT Imaging Probe.
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ABSTRACT:
SUBMITTER: Park JA
PROVIDER: S-EPMC4025745 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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Heteronuclear Gd-(99m)Tc Complex of DTPA-Bis(histidylamide) Conjugate as a Bimodal MR/SPECT Imaging Probe.
Park Ji-Ae JA Kim Jung Young JY Kim Hee-Kyung HK Lee Wonho W Lim Sang Moo SM Chang Yongmin Y Kim Tae-Jeong TJ Kim Kyeong Min KM
ACS medicinal chemistry letters 20120227 4
The work describes the synthesis and in vivo application of heterotrimetallic complexes of the type {Gd(H2O)[(M(H2O)(CO)3)2(1)]} {1 = DTPA-bis(histidyl-amide); M = Re (3a); (99m)Tc (3b)} for dual modality MR/SPECT imaging. Here, the DTPA-bis(histidylamide) conjugate functions as a trinucleating chelate incorporating Gd in the DTPA core with Re or (99m)Tc in the pair of histidylamide side arms. The two complexes are chemically equivalent as revealed by HPLC, and their "cocktail mixture" (3a + 3b) ...[more]
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