Ontology highlight
ABSTRACT:
SUBMITTER: Kondo J
PROVIDER: S-EPMC4025859 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Kondo Jiro J Koganei Mai M Kasahara Tomoko T
ACS medicinal chemistry letters 20120802 9
Sisomicin with an unsaturated sugar ring I displays better antibacterial activity than other structurally related aminoglycosides, such as gentamicin, tobramycin, and amikacin. In the present study, we have confirmed by X-ray analyses that the binding mode of sisomicin is basically similar but not identical to that of the related compounds having saturated ring I. A remarkable difference is found in the stacking interaction between ring I and G1491. While the typical saturated ring I with a chai ...[more]