Ontology highlight
ABSTRACT:
SUBMITTER: de Villiers M
PROVIDER: S-EPMC4027574 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
de Villiers Marianne M Macuamule Cristiano C Spry Christina C Hyun Yoo-Min YM Strauss Erick E Saliba Kevin J KJ
ACS medicinal chemistry letters 20130617 8
Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has demonstrated that pantothenamides inhibit the growth of blood-stage Plasmodium falciparum with submicromolar potency by exerting an effect on pantothenic acid utilization, but only when the pantetheinase present in the growth medium has been inactivated. Here, we demonstrate that small modifications of the pantothenamide c ...[more]