Ontology highlight
ABSTRACT:
SUBMITTER: Min-Oo G
PROVIDER: S-EPMC4828244 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Experimental parasitology 20100226 4
In mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of P. chabaudi and significantly increases survival. Similarly, a short exposure of Plasmodium to cysteamine ex vivo is sufficient to suppress parasite infectivity in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine pre ...[more]