Ontology highlight
ABSTRACT:
SUBMITTER: Miranda D
PROVIDER: S-EPMC4027774 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Miranda Daniela D Capela Rita R Albuquerque Inês S IS Meireles Patrícia P Paiva Isa I Nogueira Fátima F Amewu Richard R Gut Jiri J Rosenthal Philip J PJ Oliveira Rudi R Mota Maria M MM Moreira Rui R Marti Francesc F Prudêncio Miguel M O'Neill Paul M PM Lopes Francisca F
ACS medicinal chemistry letters 20131220 2
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity. These hybrid compounds showed high potency against both exoerythrocytic and erythrocytic forms of malaria parasites, comparable to r ...[more]