Ontology highlight
ABSTRACT:
SUBMITTER: Reader J
PROVIDER: S-EPMC7801607 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Reader Janette J van der Watt Mariëtte E ME Taylor Dale D Le Manach Claire C Mittal Nimisha N Ottilie Sabine S Theron Anjo A Moyo Phanankosi P Erlank Erica E Nardini Luisa L Venter Nelius N Lauterbach Sonja S Bezuidenhout Belinda B Horatscheck Andre A van Heerden Ashleigh A Spillman Natalie J NJ Cowell Anne N AN Connacher Jessica J Opperman Daniel D Orchard Lindsey M LM Llinás Manuel M Istvan Eva S ES Goldberg Daniel E DE Boyle Grant A GA Calvo David D Mancama Dalu D Coetzer Theresa L TL Winzeler Elizabeth A EA Duffy James J Koekemoer Lizette L LL Basarab Gregory G Chibale Kelly K Birkholtz Lyn-Marié LM
Nature communications 20210111 1
Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodium asexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. Unique chemotypes were identified with both multistage activity or stage-specific activity, including structurally diverse gametocyte-targeted compound ...[more]