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Retinoid X Receptor Antagonists.

ABSTRACT: Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC6121510 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Retinoid X Receptor Antagonists.

Watanabe Masaki M   Kakuta Hiroki H  

International journal of molecular sciences 20180810 8

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research. ...[more]

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