Ontology highlight
ABSTRACT:
SUBMITTER: Teske KA
PROVIDER: S-EPMC6008168 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20171219 3
The vitamin D receptor is a nuclear hormone receptor that regulates cell proliferation, cell differentiation and calcium homeostasis. The receptor is endogenously activated by 1,25-dihydroxyvitamin D<sub>3</sub>, which induces transcription of VDR targets genes regulated by coactivator binding. VDR antagonists and partial agonists have been developed based on the secosteroid scaffold of vitamin D. Only a few non-secosteroid VDR antagonists are known. Herein, we report the rational design of non- ...[more]