Ontology highlight
ABSTRACT:
SUBMITTER: Migdalovich D
PROVIDER: S-EPMC4028036 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Migdalovich Dimitry D Moss Arthur J AJ Lopes Coeli M CM Costa Jason J Ouellet Gregory G Barsheshet Alon A McNitt Scott S Polonsky Slava S Robinson Jennifer L JL Zareba Wojciech W Ackerman Michael J MJ Benhorin Jesaia J Kaufman Elizabeth S ES Platonov Pyotr G PG Shimizu Wataru W Towbin Jeffrey A JA Vincent G Michael GM Wilde Arthur A M AA Goldenberg Ilan I
Heart rhythm 20110325 10
<h4>Background</h4>Men and women with type 2 long QT syndrome (LQT2) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2.<h4>Objective</h4>This study sought to risk-stratify LQT2 patients for life-threatening cardiac events based on clinical and genetic information.<h4>Methods</h4>The risk for life-threatening cardiac events from birth throu ...[more]