Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC5742310 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Wang Meng M Szepietowska Barbara B Polonsky Bronislava B McNitt Scott S Moss Arthur J AJ Zareba Wojciech W Auerbach David S DS
The American journal of cardiology 20171113 2
Patients with long QT syndrome (LQTS) are at a high risk of cardiac events. Many patients with LQTS are treated with antidepressant drugs (ADs). We investigated the LQTS genotype-specific risk of recurrent cardiac arrhythmic events (CAEs) associated with AD therapy. The study included 59 LQT1 and 72 LQT2 patients from the Rochester-based LQTS Registry with corrected QT (QT<sub>c</sub>) prolongation and a history of AD therapy. Using multivariate Anderson-Gill models, we estimated the LQTS genoty ...[more]