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Risk of Cardiac Events Associated With Antidepressant Therapy in Patients With Long QT Syndrome.

ABSTRACT: Patients with long QT syndrome (LQTS) are at a high risk of cardiac events. Many patients with LQTS are treated with antidepressant drugs (ADs). We investigated the LQTS genotype-specific risk of recurrent cardiac arrhythmic events (CAEs) associated with AD therapy. The study included 59 LQT1 and 72 LQT2 patients from the Rochester-based LQTS Registry with corrected QT (QTc) prolongation and a history of AD therapy. Using multivariate Anderson-Gill models, we estimated the LQTS genotype-specific risk of recurrent CAEs (ventricular tachyarrhythmias, aborted cardiac arrest, or sudden cardiac death) associated with time-dependent ADs. Specifically, we examined the risk associated with all ADs, selective serotonin reuptake inhibitor (SSRI), and ADs classified on the CredibleMeds list (www.CredibleMeds.org) as "Conditional" or "Known risk of Torsades de pointes (TdP)." After adjusting for baseline QTc duration, sex, and time-dependent beta-blocker usage, there was an increased risk of recurrent CAEs associated with ADs in LQT1 patients (hazard ratio?=?3.67, 95% confidence interval 1.98-6.82, p?

SUBMITTER: Wang M 

PROVIDER: S-EPMC5742310 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Risk of Cardiac Events Associated With Antidepressant Therapy in Patients With Long QT Syndrome.

Wang Meng M   Szepietowska Barbara B   Polonsky Bronislava B   McNitt Scott S   Moss Arthur J AJ   Zareba Wojciech W   Auerbach David S DS  

The American journal of cardiology 20171113 2

Patients with long QT syndrome (LQTS) are at a high risk of cardiac events. Many patients with LQTS are treated with antidepressant drugs (ADs). We investigated the LQTS genotype-specific risk of recurrent cardiac arrhythmic events (CAEs) associated with AD therapy. The study included 59 LQT1 and 72 LQT2 patients from the Rochester-based LQTS Registry with corrected QT (QT<sub>c</sub>) prolongation and a history of AD therapy. Using multivariate Anderson-Gill models, we estimated the LQTS genoty  ...[more]

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