Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.

ABSTRACT: Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIII?. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.

SUBMITTER: MacLeod AM 

PROVIDER: S-EPMC4030314 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature