Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC4030375 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Yang Zhe Z Horton John R JR Zhou Lan L Zhang Xu Jia XJ Dong Aiping A Zhang Xing X Schlagman Samuel L SL Kossykh Valeri V Hattman Stanley S Cheng Xiaodong X
Nature structural biology 20030824 10
DNA-adenine methylation at certain GATC sites plays a pivotal role in bacterial and phage gene expression as well as bacterial virulence. We report here the crystal structures of the bacteriophage T4Dam DNA adenine methyltransferase (MTase) in a binary complex with the methyl-donor product S-adenosyl-L-homocysteine (AdoHcy) and in a ternary complex with a synthetic 12-bp DNA duplex and AdoHcy. T4Dam contains two domains: a seven-stranded catalytic domain that harbors the binding site for AdoHcy ...[more]