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Understanding DNA replication by the bacteriophage T4 replisome.


ABSTRACT: The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.

SUBMITTER: Benkovic SJ 

PROVIDER: S-EPMC5682956 | biostudies-literature |

REPOSITORIES: biostudies-literature

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