Ontology highlight
ABSTRACT:
SUBMITTER: Tilwani RK
PROVIDER: S-EPMC4031018 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Tilwani Reshma K RK Bader Dan L DL Chowdhury Tina T TT
Journal of functional biomaterials 20120105 1
Biomechanical signals play an important role in normal disc metabolism and pathology. For instance, nucleus pulposus (NP) cells will regulate metabolic activities and maintain a balance between the anabolic and catabolic cascades. The former involves factors such as transforming growth factor-β (TGFβ) and mechanical stimuli, both of which are known to regulate matrix production through autocrine and paracrine mechanisms. The present study examined the combined effect of TGFβ and mechanical loadi ...[more]