Ontology highlight
ABSTRACT:
SUBMITTER: Consonni SV
PROVIDER: S-EPMC4032295 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Consonni Sarah V SV Brouwer Patricia M PM van Slobbe Eleonora S ES Bos Johannes L JL
PloS one 20140523 5
PDZGEF is a guanine nucleotide exchange factor for the small G protein Rap. It was recently found that PDZGEF contributes to establishment of intestinal epithelial polarity downstream of the kinase Lkb1. By binding to phosphatidic acid enriched at the apical membrane, PDZGEF locally activates Rap2a resulting in induction of brush border formation via a pathway that includes the polarity players TNIK, Mst4 and Ezrin. Here we show that the PDZ domain of PDZGEF is essential and sufficient for targe ...[more]