Ontology highlight
ABSTRACT:
SUBMITTER: Brachtl G
PROVIDER: S-EPMC4032465 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Annals of hematology 20131128 3
The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophys ...[more]