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The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

ABSTRACT: The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophysiology of the disease. The expression of CD38 and CD49d is associated in the majority of cases, and they exist as part of macromolecular complexes. Here, we review the current evidence for the individual and associated contributions of these molecules to CLL pathophysiology.

SUBMITTER: Brachtl G

PROVIDER: S-EPMC4032465 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

Brachtl Gabriele G Piñón Hofbauer Josefina J Greil Richard R Hartmann Tanja Nicole TN Hartmann Tanja Nicole TN

Annals of hematology 20131128 3

The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophys ...[more]

PMID: 24288111

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CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.

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Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment.

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