Ontology highlight
ABSTRACT:
SUBMITTER: Tissino E
PROVIDER: S-EPMC7228464 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Blood 20200401 15
CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression. In the present study, we analyzed a cohort of 1630 CLL samples and identified the presence of ∼20% of CLL cases (n = 313) characterized by a bimodal expression of CD49d, that is, concomitant presence of a CD49d+ ...[more]