Ontology highlight
ABSTRACT:
SUBMITTER: Mele S
PROVIDER: S-EPMC6039665 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Blood advances 20180701 13
CD38 is a transmembrane exoenzyme that is associated with poor prognosis in chronic lymphocytic leukemia (CLL). High CD38 levels in CLL cells are linked to increased cell migration, but the molecular basis is unknown. CD38 produces nicotinic acid adenine dinucleotide phosphate and adenosine 5'-diphosphate-ribose, both of which can act to increase intracellular Ca<sup>2+</sup> levels. Here we show that CD38 expression increases basal intracellular Ca<sup>2+</sup> levels and stimulates CLL cell mi ...[more]