Ontology highlight
ABSTRACT:
SUBMITTER: Miller RA
PROVIDER: S-EPMC4032600 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Miller Richard A RA Harrison David E DE Astle Clinton M CM Fernandez Elizabeth E Flurkey Kevin K Han Melissa M Javors Martin A MA Li Xinna X Nadon Nancy L NL Nelson James F JF Pletcher Scott S Salmon Adam B AB Sharp Zelton Dave ZD Van Roekel Sabrina S Winkleman Lynn L Strong Randy R
Aging cell 20140209 3
Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug. Some of the endocrine and metabolic changes seen in diet-restricted mice are not seen i ...[more]