Ontology highlight
ABSTRACT:
SUBMITTER: Birkisdottir MB
PROVIDER: S-EPMC7884048 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Aging cell 20210123 2
Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve life span nor healthspan of DNA repair-deficient Ercc1<sup>∆/-</sup> mice, contrary to DR tested in parallel. Rapamycin interventions focusing on dosage, gender, and timing all were un ...[more]