Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC2703712 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Wu Xiaoyang X Kodama Atsuko A Fuchs Elaine E
Cell 20081001 1
Coordinated interactions between microtubule (MT) and actin cytoskeletons are involved in many polarized cellular processes. Spectraplakins are enormous (>500 kDa) proteins able to bind both MTs and actin filaments (F-actin) directly. To elucidate the physiological significance and functions of mammalian spectraplakin ACF7, we've conditionally targeted it in skin epidermis. Intriguingly, ACF7 deficiency compromises the targeting of microtubules along F-actin to focal adhesions (FAs), stabilizes ...[more]