Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe T
PROVIDER: S-EPMC4034423 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Watanabe Tomoko T Biggins John S JS Tannan Neeta Bala NB Srinivas Shankar S
Development (Cambridge, England) 20140601 11
The formation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events during mammalian embryogenesis. It is believed that the orientation of division of polarised blastomeres in the 8- and 16-cell stage embryo determines the fate of daughter cells, based on how asymmetrically distributed lineage determinants are segregated. To investigate the relationship between angle of division and subsequent fate in unperturbed embryos, we constructed cellular resolution dig ...[more]