Ontology highlight
ABSTRACT:
SUBMITTER: Lohr JG
PROVIDER: S-EPMC4034575 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Lohr Jens G JG Adalsteinsson Viktor A VA Cibulskis Kristian K Choudhury Atish D AD Rosenberg Mara M Cruz-Gordillo Peter P Francis Joshua M JM Zhang Cheng-Zhong CZ Shalek Alex K AK Satija Rahul R Trombetta John J JJ Lu Diana D Tallapragada Naren N Tahirova Narmin N Kim Sora S Blumenstiel Brendan B Sougnez Carrie C Lowe Alarice A Wong Bang B Auclair Daniel D Van Allen Eliezer M EM Nakabayashi Mari M Lis Rosina T RT Lee Gwo-Shu M GS Li Tiantian T Chabot Matthew S MS Ly Amy A Taplin Mary-Ellen ME Clancy Thomas E TE Loda Massimo M Regev Aviv A Meyerson Matthew M Hahn William C WC Kantoff Philip W PW Golub Todd R TR Getz Gad G Boehm Jesse S JS Love J Christopher JC
Nature biotechnology 20140420 5
Comprehensive analyses of cancer genomes promise to inform prognoses and precise cancer treatments. A major barrier, however, is inaccessibility of metastatic tissue. A potential solution is to characterize circulating tumor cells (CTCs), but this requires overcoming the challenges of isolating rare cells and sequencing low-input material. Here we report an integrated process to isolate, qualify and sequence whole exomes of CTCs with high fidelity using a census-based sequencing strategy. Power ...[more]