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Nanofibrous microposts and microwells of controlled shapes and their hybridization with hydrogels for cell encapsulation.

ABSTRACT: A simple, robust, and cost-effective method is developed to fabricate nanofibrous micropatterns particularly microposts and microwells of controlled shapes. The key to this method is the use of an easily micropatternable and intrinsically conductive metal alloy as a template to collect electrospun fibers. The micropatterned alloy allows conformal fiber deposition with high fidelity on its topographical features and in situ formation of diverse, free-standing micropatterned nanofibrous membranes. Interestingly, these membranes can serve as structural frames to form robust hydrogel micropatterns that may otherwise be fragile on their own. These hybrid micropatterns represent a new platform for cell encapsulation where the nanofiber frames enhance the mechanical integrity of hydrogel and the micropatterns provide additional surface area for mass transfer and cell loading.

SUBMITTER: Song W

PROVIDER: S-EPMC4039346 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Nanofibrous microposts and microwells of controlled shapes and their hybridization with hydrogels for cell encapsulation.

Song Wei W An Duo D Kao Der-I DI Lu Yen-Chun YC Dai Guohao G Chen Shuibing S Ma Minglin M

ACS applied materials & interfaces 20140509 10

A simple, robust, and cost-effective method is developed to fabricate nanofibrous micropatterns particularly microposts and microwells of controlled shapes. The key to this method is the use of an easily micropatternable and intrinsically conductive metal alloy as a template to collect electrospun fibers. The micropatterned alloy allows conformal fiber deposition with high fidelity on its topographical features and in situ formation of diverse, free-standing micropatterned nanofibrous membranes. ...[more]

PMID: 24806031

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