Ontology highlight
ABSTRACT:
SUBMITTER: Basilio D
PROVIDER: S-EPMC4040230 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20140420 5
CLC-type exchangers mediate transmembrane Cl(-) transport. Mutations altering their gating properties cause numerous genetic disorders. However, their transport mechanism remains poorly understood. In conventional models, two gates alternatively expose substrates to the intra- or extracellular solutions. A glutamate was identified as the only gate in the CLCs, suggesting that CLCs function by a nonconventional mechanism. Here we show that transport in CLC-ec1, a prokaryotic homolog, is inhibited ...[more]