Ontology highlight
ABSTRACT:
SUBMITTER: Abraham SJ
PROVIDER: S-EPMC4398623 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Abraham Sherwin J SJ Cheng Ricky C RC Chew Thomas A TA Khantwal Chandra M CM Liu Corey W CW Gong Shimei S Nakamoto Robert K RK Maduke Merritt M
Journal of biomolecular NMR 20150129 3-4
CLC transporters catalyze the exchange of Cl(-) for H(+) across cellular membranes. To do so, they must couple Cl(-) and H(+) binding and unbinding to protein conformational change. However, the sole conformational changes distinguished crystallographically are small movements of a glutamate side chain that locally gates the ion-transport pathways. Therefore, our understanding of whether and how global protein dynamics contribute to the exchange mechanism has been severely limited. To overcome t ...[more]