Ontology highlight
ABSTRACT:
SUBMITTER: Majumder S
PROVIDER: S-EPMC4041589 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20140401 7
Distinct differences between how model proteins interact in-cell and in vitro suggest that the cytosol might have a profound effect in modulating protein-protein and/or protein-ligand interactions that are not observed in vitro. Analyses of in-cell NMR spectra of target proteins interacting with physiological partners are further complicated by low signal-to-noise ratios, and the long overexpression times used in protein-protein interaction studies may lead to changes in the in-cell spectra over ...[more]