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Differences in ovarian hormones in relation to parity and time since last birth.


ABSTRACT: To examine ovarian function in relation to parity and time since last birth.Cross-sectional study.Health-care program in California.346 naturally cycling women, aged 18 to 39 years.None.Mean follicular urinary estradiol metabolite concentration (E1C) (cycle days -8 to -1), mean luteal progesterone metabolite concentration (PdG) (days 0 to +10), and cycle phase lengths in ovulatory cycles.After the women had collected daily urine samples for up to eight menstrual cycles, we measured the E1C and PdG using enzyme-linked immunoassay. The cycle phase lengths were calculated from the hormone profiles and daily diaries. Women who had given birth within the previous 3 years had lower E1C than the nulliparous women and women who last given birth >3 years earlier. Among the parous women, E1C was positively associated with the time since last birth. Women who last gave birth >3 years earlier had longer follicular phases than the nulliparous women. There were no associations between parity and PdG or luteal phase length.Our cross-sectional data suggest that ovarian function differs in nulliparous and parous women and is positively associated with the time since last birth. Longitudinal research is needed to explore within-woman changes in ovarian function prepartum and postpartum.

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC4041832 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Differences in ovarian hormones in relation to parity and time since last birth.

Barrett Emily S ES   Parlett Lauren E LE   Windham Gayle C GC   Swan Shanna H SH  

Fertility and sterility 20140328 6


<h4>Objective</h4>To examine ovarian function in relation to parity and time since last birth.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Health-care program in California.<h4>Patient(s)</h4>346 naturally cycling women, aged 18 to 39 years.<h4>Intervention(s)</h4>None.<h4>Main outcome measure(s)</h4>Mean follicular urinary estradiol metabolite concentration (E1C) (cycle days -8 to -1), mean luteal progesterone metabolite concentration (PdG) (days 0 to +10), and cycle phase lengths in ov  ...[more]

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