Ontology highlight
ABSTRACT:
SUBMITTER: Lasagna-Reeves CA
PROVIDER: S-EPMC4046102 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Lasagna-Reeves Cristian A CA Castillo-Carranza Diana L DL Sengupta Urmi U Sarmiento Jose J Troncoso Juan J Jackson George R GR Kayed Rakez R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120117 5
Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD); however, the relationship between NFTs and disease progression remains controversial. Analyses of tau animal models suggest that phenotypes coincide with accumulation of soluble aggregated tau species but not the accumulation of NFTs. The pathological role of prefilamentous tau aggregates, e.g., tau oligomeric intermediates, is poorly understood, in part because of methodological challenges. Here, we engineer ...[more]