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Protein-Capped Metal Nanoparticles Inhibit Tau Aggregation in Alzheimer's Disease.


ABSTRACT: The Alzheimer's disease (AD) therapeutic research is yielding a large number of potent molecules. The nanoparticle-based therapeutics against the protein aggregation in AD is also taking a lead especially with amyloid-? as a primary target. In this work, we have screened for the first time protein-capped (PC) metal nanoparticles for their potency in inhibiting Tau aggregation in vitro. We present a novel function of PC-Fe3O4 and PC-CdS nanoparticles as potent Tau aggregation inhibitors by fluorescence spectrometry, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and electron microscopy. We demonstrate that the biologically synthesized PC-metal nanoparticles, especially iron oxide do not affect the viability of neuroblastoma cells. Moreover, PC-CdS nanoparticles show dual properties of inhibition and disaggregation of Tau. Thus, the nanoparticles can take a lead as potent Tau aggregation inhibitors and can be modified for specific drug delivery due to their very small size. The current work presents unprecedented strategy to design anti-Tau aggregation drugs, which provides interesting insights to understand the role of biological nanostructures in Alzheimer's disease.

SUBMITTER: Sonawane SK 

PROVIDER: S-EPMC6682074 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Protein-Capped Metal Nanoparticles Inhibit Tau Aggregation in Alzheimer's Disease.

Sonawane Shweta Kishor SK   Ahmad Absar A   Chinnathambi Subashchandrabose S  

ACS omega 20190729 7


The Alzheimer's disease (AD) therapeutic research is yielding a large number of potent molecules. The nanoparticle-based therapeutics against the protein aggregation in AD is also taking a lead especially with amyloid-β as a primary target. In this work, we have screened for the first time protein-capped (PC) metal nanoparticles for their potency in inhibiting Tau aggregation in vitro. We present a novel function of PC-Fe<sub>3</sub>O<sub>4</sub> and PC-CdS nanoparticles as potent Tau aggregatio  ...[more]

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