Ontology highlight
ABSTRACT:
SUBMITTER: Stead MA
PROVIDER: S-EPMC4046208 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Stead Mark A MA Wright Stephanie C SC
Bioscience reports 20140605 3
Nac1 (nucleus accumbens 1) is a POZ (poxvirus and zinc finger)-domain transcriptional repressor that is expressed at high levels in ovarian serous carcinoma. Here we identify Nac1 as a novel interacting partner of the POZ-domain transcriptional activator, Miz1 (Myc-interacting zinc-finger protein 1), and using chemical crosslinking we show that this association is mediated by a heterodimeric interaction of the Nac1 and Miz1 POZ domains. Nac1 is found in discrete bodies within the nucleus of mamm ...[more]