Ontology highlight
ABSTRACT:
SUBMITTER: Stead MA
PROVIDER: S-EPMC4259219 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20141114 Pt 12
The POZ domain is an evolutionarily conserved protein-protein interaction domain that is found in approximately 40 mammalian transcription factors. POZ domains mediate both homodimerization and the heteromeric interactions of different POZ-domain transcription factors with each other. Miz1 is a POZ-domain transcription factor that regulates cell-cycle arrest and DNA-damage responses. The activities of Miz1 are altered by its interaction with the POZ-domain transcriptional repressors BCL6 and NAC ...[more]