Ontology highlight
ABSTRACT:
SUBMITTER: Stead MA
PROVIDER: S-EPMC2675581 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Stead Mark A MA Carr Stephen B SB Wright Stephanie C SC
Acta crystallographica. Section F, Structural biology and crystallization communications 20090424 Pt 5
Nac1 is a POZ-domain transcription factor that is involved in the self-renewal of embryonic stem cells. It is overexpressed in ovarian serous carcinoma and targeting the interactions of its POZ domain is a potential therapeutic strategy. Nac1 lacks a zinc-finger DNA-binding domain and thereby differs from most other POZ-domain transcription factors. Here, the crystal structure of the Nac1 POZ domain at 2.1 A resolution is reported. The Nac1 POZ domain crystallized as a dimer in which the interac ...[more]