Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4606798 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20151015
Published studies of lipid-protein interactions have mainly focused on lipid binding to an individual site of the protein. Here, we show that a lipid can migrate between different binding sites in a protein and this migration modulates protein function. Voltage-gated potassium (Kv) channels have several potential binding sites for phosphatidylinositol-4,5-bisphosphate (PIP2). Our molecular dynamics (MD) simulations on the KCNQ2 channel reveal that PIP2 preferentially binds to the S4-S5 linker wh ...[more]