Unknown

Dataset Information

0

Systems biology approaches to develop innovative strategies for lung cancer therapy.


ABSTRACT: Lung cancer (LC) is a number one killer of cancer-related death among men and women worldwide. Major advances have been made in the diagnosis, staging and use of surgery for LC, but systemic chemotherapy and radiotherapy alone or in combination with some targeted agents remains the core treatment of advanced LC. Unfortunately, in spite of improved diagnosis, surgical methods and new treatments, mortality is still extremely high among LC patients. To understand the precise functioning of signaling pathways associated with resistance to current treatments in LC, as well as to identify novel treatment regimens, a holistic approach to analyze signaling networks should be applied. Here, we describe systems biology-based approaches to generate biomarkers and novel therapeutic targets in LC, as well as how this may contribute to personalized treatment for this malignancy.

SUBMITTER: Viktorsson K 

PROVIDER: S-EPMC4047893 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Systems biology approaches to develop innovative strategies for lung cancer therapy.

Viktorsson K K   Lewensohn R R   Zhivotovsky B B  

Cell death & disease 20140529


Lung cancer (LC) is a number one killer of cancer-related death among men and women worldwide. Major advances have been made in the diagnosis, staging and use of surgery for LC, but systemic chemotherapy and radiotherapy alone or in combination with some targeted agents remains the core treatment of advanced LC. Unfortunately, in spite of improved diagnosis, surgical methods and new treatments, mortality is still extremely high among LC patients. To understand the precise functioning of signalin  ...[more]

Similar Datasets

| S-EPMC3615902 | biostudies-literature
2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress
| S-EPMC2802734 | biostudies-literature
| S-EPMC3553555 | biostudies-literature
| S-EPMC4752481 | biostudies-literature
| S-EPMC2862988 | biostudies-literature
| S-EPMC4810074 | biostudies-literature
2011-04-19 | GSE21411 | GEO
| S-EPMC6293490 | biostudies-literature
2011-04-19 | E-GEOD-21411 | biostudies-arrayexpress