Ontology highlight
ABSTRACT:
SUBMITTER: Hong S
PROVIDER: S-EPMC4049084 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Molecular cell 20130801 4
Recombinational repair of spontaneous double-strand breaks (DSBs) exhibits sister bias. DSB-initiated meiotic recombination exhibits homolog bias. Physical analysis in yeast reveals that, in both cases, the recombination reaction intrinsically gives homolog bias. From this baseline default, cohesin intervenes to confer sister bias, likely independent of cohesion. In meiosis, cohesin's sister-biasing effect is counteracted by RecA homolog Rad51 and its mediators, plus meiotic RecA homolog Dmc1, w ...[more]