Ontology highlight
ABSTRACT:
SUBMITTER: Surman SL
PROVIDER: S-EPMC4049130 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Surman S L SL Jones B G BG Sealy R E RE Rudraraju R R Hurwitz J L JL
Vaccine 20140321 22
Vitamin A deficiency (VAD) is a leading cause of pediatric morbidity and mortality due to infectious diseases. Recent pre-clinical studies have revealed that VAD impairs mucosal IgA-producing antibody forming cell (AFC) responses toward a paramyxovirus vaccine in the upper respiratory tract (URT), thus impeding a first line of defense at the pathogen's point-of-entry. The studies described here tested the hypothesis that VAD may also impair immune responses after FluMist vaccinations. Results sh ...[more]