Ontology highlight
ABSTRACT:
SUBMITTER: Will M
PROVIDER: S-EPMC4049524 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Will Marie M Qin Alice Can Ran AC Toy Weiyi W Yao Zhan Z Rodrik-Outmezguine Vanessa V Rodrik-Outmezguine Vanessa V Schneider Claudia C Huang Xiaodong X Monian Prashant P Jiang Xuejun X de Stanchina Elisa E Baselga José J Liu Ningshu N Chandarlapaty Sarat S Rosen Neal N
Cancer discovery 20140116 3
The effects of selective phosphoinositide 3-kinase (PI3K) and AKT inhibitors were compared in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of AKT, relief of feedback inhibition of receptor tyrosine kinases, and growth arrest. However, only the PI3K inhibitors caused rapid induction of cell death. In seeking a mechanism for this phenomenon, we found that PI3K inhibition, but not AKT inhibition, causes rapid inhibition of wild-type RAS and of RAF-MEK-ERK sign ...[more]