Ontology highlight
ABSTRACT:
SUBMITTER: Scott RS
PROVIDER: S-EPMC4050282 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Scott Ricardo S RS Henneberger Christian C Padmashri Ragunathan R Anders Stefanie S Jensen Thomas P TP Rusakov Dmitri A DA
Nature communications 20140523
Action potential (AP) generation is the key to information-processing in the brain. Although APs are normally initiated in the axonal initial segment, developmental adaptation or prolonged network activity may alter the initiation site geometry thus affecting cell excitability. Here we find that hippocampal dentate granule cells adapt their spiking threshold to the kinetics of the ongoing dendrosomatic excitatory input by expanding the AP-initiation area away from the soma while also deceleratin ...[more]