Ontology highlight
ABSTRACT:
SUBMITTER: Kazmier K
PROVIDER: S-EPMC4050370 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Kazmier Kelli K Sharma Shruti S Quick Matthias M Islam Shahidul M SM Roux Benoît B Weinstein Harel H Javitch Jonathan A JA McHaourab Hassane S HS
Nature structural & molecular biology 20140420 5
The leucine transporter (LeuT) from Aquifex aeolicus is a bacterial homolog of neurotransmitter/sodium symporters (NSSs) that catalyze reuptake of neurotransmitters at the synapse. Crystal structures of wild-type and mutants of LeuT have been interpreted as conformational states in the coupled transport cycle. However, the mechanistic identities inferred from these structures have not been validated, and the ligand-dependent conformational equilibrium of LeuT has not been defined. Here, we used ...[more]