Ontology highlight
ABSTRACT:
SUBMITTER: Fan J
PROVIDER: S-EPMC8105300 | biostudies-literature | 2021 Jan-Jun
REPOSITORIES: biostudies-literature
Fan Jianjun J Xiao Yang Y Quick Matthias M Yang Yuwei Y Sun Ziyi Z Javitch Jonathan A JA Zhou Xiaoming X
The Journal of biological chemistry 20210101
The neurotransmitter:sodium symporter (NSS) homolog LeuT from Aquifex aeolicus has proven to be a valuable model for studying the transport mechanism of the NSS family. Crystal structures have captured LeuT in key conformations visited during the transport cycle, allowing for the construction of a nearly complete model of transport, with much of the conformational dynamics studied by computational simulations. Here, we report crystal structures of LeuT representing new intermediate conformations ...[more]