Ontology highlight
ABSTRACT:
SUBMITTER: Thomas JR
PROVIDER: S-EPMC4177338 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Thomas James R JR Gedeon Patrick C PC Madura Jeffry D JD
Proteins 20140509 10
The bacterial leucine transporter LeuT retains significant secondary structure similarities to the human monoamine transporters (MAT) such as the dopamine and serotonin reuptake proteins. The primary method of computational study of the MATs has been through the use of the crystallized LeuT structure. Different conformations of LeuT can give insight into mechanistic details of the MAT family. A conformational sampling performed through accelerated molecular dynamics simulations testing different ...[more]