Ontology highlight
ABSTRACT:
SUBMITTER: Sontag CJ
PROVIDER: S-EPMC4050489 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Sontag Christopher J CJ Uchida Nobuko N Cummings Brian J BJ Anderson Aileen J AJ
Stem cell reports 20140418 5
The microenvironment is a critical mediator of stem cell survival, proliferation, migration, and differentiation. The majority of preclinical studies involving transplantation of neural stem cells (NSCs) into the CNS have focused on injured or degenerating microenvironments, leaving a dearth of information as to how NSCs differentially respond to intact versus damaged CNS. Furthermore, single, terminal histological endpoints predominate, providing limited insight into the spatiotemporal dynamics ...[more]