Ontology highlight
ABSTRACT:
SUBMITTER: Ritt DA
PROVIDER: S-EPMC5135640 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ritt Daniel A DA Abreu-Blanco María T MT Bindu Lakshman L Durrant David E DE Zhou Ming M Specht Suzanne I SI Stephen Andrew G AG Holderfield Matthew M Morrison Deborah K DK
Molecular cell 20161123 5
Ras pathway signaling plays a critical role in cell growth control and is often upregulated in human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important effectors of Ras signaling, functioning as the initiating kinases in the ERK cascade. Here, we identify a route for the phospho-inhibition of Ras/Raf/MEK/ERK pathway signaling that is mediated by the stress-activated JNK cascade. We find that key Ras pathway components, the RasGEF Sos1 and the Rafs, are phosphorylat ...[more]