Ontology highlight
ABSTRACT:
SUBMITTER: Aytes A
PROVIDER: S-EPMC4051317 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cancer cell 20140501 5
To identify regulatory drivers of prostate cancer malignancy, we have assembled genome-wide regulatory networks (interactomes) for human and mouse prostate cancer from expression profiles of human tumors and of genetically engineered mouse models, respectively. Cross-species computational analysis of these interactomes has identified FOXM1 and CENPF as synergistic master regulators of prostate cancer malignancy. Experimental validation shows that FOXM1 and CENPF function synergistically to promo ...[more]