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Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.

ABSTRACT: The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.

SUBMITTER: Huang W

PROVIDER: S-EPMC4646845 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.

Huang Wei W Kim Seong Jong SJ Liu Joyce J Zhang Wenjun W

Organic letters 20151016 21

The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids. ...[more]

PMID: 26473429

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