Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC4051872 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chen Wenxue W Ayala-Orozco Ciceron C Biswal Nrusingh C NC Perez-Torres Carlos C Bartels Marc M Bardhan Rizia R Stinnet Gary G Liu Xian-De XD Ji Baoan B Deorukhkar Amit A Brown Lisa V LV Guha Sushovan S Pautler Robia G RG Krishnan Sunil S Halas Naomi J NJ Joshi Amit A
Nanomedicine (London, England) 20130924 8
<h4>Aim</h4>We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer.<h4>Materials & methods</h4>Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude ...[more]