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Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells.

ABSTRACT: Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported.

SUBMITTER: Coelho SC

PROVIDER: S-EPMC6161021 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells.

Coelho Sílvia Castro SC Reis Daniel Pires DP Pereira Maria Carmo MC Coelho Manuel A N MAN

Pharmaceutics 20180712 3

Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates incr ...[more]

PMID: 30002279

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